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Medical Journal Audio Podcast, (Latest) |
| Description: Volume 148 Issue 9 – Lipid monitoring in patients on statins; an interview with Paul Glasziou, MBBS, PhD, of the University of Oxford; plus a summary of all the articles in this week's issue. |
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Audio Podcast, (April 15, 2008) |
| Description: Testosterone for Treatment of Decreased Sexual Satisfaction in Women; comments from Rosemary Basson, MD, of the University of British Columbia in Vancouver, Canada; plus a summary of all the articles in this week's issue. |
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Medical Journal Audio Podcast, (April 15, 2008) |
| Description: Volume 148 Issue 8 – Testosterone for Treatment of Decreased Sexual Satisfaction in Women; comments from Rosemary Basson, MD, of the University of British Columbia in Vancouver, Canada; plus a summary of all the articles in this week's issue. |
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Audio Podcast, (April 1, 2008) |
| Description: uman Papillomavirus Infection and Cervical Cytology in Women Screened for Cervical Cancer in the United States, 2003–2005
Datta, Koutsky, Ratelle, Unger, Shlay, McClain, Weaver, Kerndt, and others
Differences in Kidney Function and Incident Hypertension: The Multi-Ethnic Study of Atherosclerosis
Kestenbaum, Rudser, de Boer, Peralta, Fried, Shlipak, Palmas, and others
Comparison of 2 Interventions for Liquid Aspiration on Pneumonia Incidence: A Randomized Trial
Robbins, Gensler, Hind, Logemann, Lindblad, Brandt, Baum, Lilienfeld, and others
ACADEMIA AND CLINIC
Exploring the Geometry of Treatment Networks
Salanti, Kavvoura, and Ioannidis
REVIEW
Systematic Review: The Effect of Preventive Lamivudine on Hepatitis B Reactivation during Chemotherapy
Loomba, Rowley, Wesley, Liang, Hoofnagle, Pucino, and Csako
PERSPECTIVE
The Case for Treating Tobacco Dependence as a Chronic Disease
Steinberg, Schmelzer, Richardson, and Foulds
Author interview:
CLINICAL GUIDELINES
Screening for Chronic Obstructive Pulmonary Disease Using Spirometry: U.S. Preventive Services Task Force Recommendation Statement
U.S. Preventive Services Task Force
Screening for Chronic Obstructive Pulmonary Disease Using Spirometry: Summary of the Evidence for the U.S. Preventive Services Task Force
Lin, Watkins, Johnson, Rodriguez, and Barton
EDITORIAL
Adding Human Papillomavirus Testing to Cytology for Primary Cervical Cancer Screening: Shooting First and Asking Questions Later
Sawaya
IN THE CLINIC
Dementia |
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Dengue Fever Seroprevalence and Risk Factors, Texas–Mexico Border, 2004, (Latest) |
| Description: Dengue fever is both endemic and underrecognized along a section of the southern Texas–Mexico border, and low income is a primary risk factor for infection. As part of a special section on Global Poverty and Human Development, Dr. Joan Marie Brunkard discusses a dengue seroprevalence survey in this region and what can be done to help prevent infection and to identify and treat those who are infected. |
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Increase in Clostridium difficile–related Mortality Rates, United States, 1999–2004, (September 1, 2007) |
| Description: Deaths related to Clostridium difficile are on the rise in the United States. Matthew Redelings from the Los Angeles County Department of Health discusses the increase and what can be done to prevent this infection. |
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Brazilian Vaccinia Viruses and Their Origins, (July 29, 2007) |
| Description: Smallpox was eradicated more than 25 years ago, but live viruses used in vaccines may have survived to cause animal and human illness today. Dr. Inger Damon, Acting Branch Chief of the Poxvirus and Rabies Branch at CDC, discusses efforts to determine origins and spread of vaccinia viruses in Brazil. |
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Strategies to Reduce Person-to-Person Transmission During Widespread Escherichia coli O157:H7 Outbreak, (June 7, 2007) |
| Description: US consumers were warned not to eat raw spinach during a 2006 E. coli O157:H7 outbreak, but additional warnings about person-to-person transmission could have reduced bacteria spread. Dr. Martin Meltzer discusses the research methods and findings and the authors' success in presenting them clearly and accurately. |
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Human Benefits of Animal Interventions for Zoonosis Control, (May 1, 2007) |
| Description: ndustrialized countries have contained recent zoonotic disease outbreaks, but countries with limited resources cannot respond adequately. Dr. Nina Marano, veterinarian and Chief, Geographic Medicine and Health Promotion Branch, CDC, comments on the focus on animal reservoirs to prevent outbreaks in developing nations. |
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Highlights, (Latest) |
Description:
- Self-monitoring of blood glucose did not improve glycemic control in patients with type 2 diabetes not treated with insulin
- Review: thiazolidinediones increase risk of heart failure in type 2 diabetes
- Review: symptoms, signs, and lab tests have moderate accuracy for detecting appendicitis in children
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Audio Commentary, (Latest) |
| Description: Original Contributions
* Effect of Folic Acid and B Vitamins on Risk of Cardiovascular Events and Total Mortality Among Women at High Risk for Cardiovascular Disease: A Randomized Trial Free
* Smoking and Smoking Cessation in Relation to Mortality in Women
* Corticosteroids and Mortality in Children With Bacterial Meningitis
* Epidemiology of Invasive Group B Streptococcal Disease in the United States, 1999-2005
Clinician's Corner
* A 50-Year-Old Man With Chronic Low Back Pain CME
* CME Course
Commentaries
* A Population Health Framework for Setting National and State Health Goals
* A Clinical Blueprint to Accelerate the Elimination of Tobacco Use
Editorials
* Homocysteine-Lowering B Vitamin Therapy in Cardiovascular Prevention—Wrong Again?
From the Archives Journals
* Sleep-Disordered Breathing and Neurobehavioral Outcomes: In Search of Clear Markers for Children at Risk |
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Audio Commentary, (April 23, 2008) |
| Description: JAMA.andnbsp;2008;299(16):1867.
Everolimus-Eluting vs Paclitaxel-Eluting Stents
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Currently available drug-eluting stents reduce but do not eliminate the risk of restenosis following percutaneous coronary intervention. Some preliminary data suggest improved clinical and angiographic outcomes with a stent that elutes the antiproliferative agent everolimus. In the SPIRIT III trial, 1002 patients with native coronary artery lesions were randomly assigned to receive either an everolimus-eluting stent or a paclitaxel-eluting stent, and angiographic follow-up was obtained 8 months after stent placement. Stone and colleagues (SEE ARTICLE) report that compared with the paclitaxel-eluting stent, the everolimus-eluting stent was associated with reduced angiographic in-segment late loss and similar rates of target vessel failure. In an editorial, Patel and Holmes (SEE ARTICLE) discuss the importance of assessing outcomes in broadly representative patient populations and long-term follow-up to ensure the safety and efficacy of interventional devices.
Comparison of Treatments for Anal Cancer
Concurrent fluorouracil/mitomycin plus radiation is the standard primary therapy for localized anal cancer and is associated with a 5-year disease-free survival rate of approximately 65%. Results of several pilot studies suggested that disease-free survival might be improved with induction chemotherapy prior to concurrent chemoradiation. Ajani and colleagues conducted a multicenter trial in which patients with anal cancer were randomly assigned to standard therapy with concurrent fluorouracil/mitomycin plus radiation or experimental therapy with fluorouracil-cisplatin induction chemotherapy followed by the same chemotherapy and concurrent radiation. The authors report that compared with standard mitomycin-based therapy, cisplatin-based therapy did not improve disease-free survival and was associated with higher rates of colostomy.
(SEE ARTICLE)
Medicare Part D: Beneficiaries' Knowledge and Costs
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Medicare's prescription drug benefit (Part D) contains complex and high-level cost sharing provisions, including a coverage gap. Results of 2 studies that assessed Medicare beneficiaries' understanding of these provisions and the effects of Part D on personal spending for drugs and basic needs are reported in this issue. Hsu and colleagues (SEE ARTICLE) surveyed Medicare enrollees in the Kaiser Permanente-Northern California health system and found that the beneficiaries had limited knowledge of the Part D cost-sharing provisions or the meaning of the coverage gap, and more than one-third reported cost-coping behaviors such as switching to a cheaper drug or reducing drug adherence. Madden and colleagues (SEE ARTICLE) report results of an analysis of national data to assess Part D enrollees' cost-related medication nonadherence and spending on basic needs in the first year of coverage. The authors found evidence for small but significant decreases in cost-related medication nonadherence and the need to spend less on necessities to afford medications. In an editorial, Goldman and Joyce (SEE ARTICLE) discuss evidence relating to the success and deficiencies of Medicare Part D.
CLINICIAN'S CORNER
Treatment of Soil-Transmitted Helminth Infections
A systematic review and meta-analysis to assess the efficacies of currently recommended single-dose, oral preventive therapies against infections caused by the soil-transmitted helminthes Ascaris lumbricoides, hookworm, and Trichuris trichiura.
(SEE ARTICLE)
A Piece of My Mind
"My ass is Jimmy, a shy miniature donkey who has been the companion of my horse, Indy, on my 20-acre farm for almost four years." From "Thank Goodness for My Ass."
(SEE ARTICLE)
Medical News andamp; Perspectives
Scientists are assessing strategies to better serve veterans, soldiers returning from active duty, and others with posttraumatic stress disorder by boosting screening and care for this condition in primary care settings.
(SEE ARTICLE)
Commentary
Limits of proposed FDA guidelines on off-label promotion
(SEE ARTICLE)
Editorial
Preserving confidentiality in the peer review process
(SEE ARTICLE)
Author in the Room Teleconference
Join Barbara Howard, PhD, and William Howard, MD, on May 21, 2008, from 2 to 3 PM eastern time to discuss lower blood pressure and cholesterol targets in diabetes. To register, go to http://www.ihi.org/AuthorintheRoom.
Audio Commentary
Dr DeAngelis summarizes and comments on this week's issue. Go to http://jama.ama-assn.org/misc/audiocommentary.dtl
Readers Respond
How would you manage a 50-year-old man with chronic low back pain? Go to www.jama.com to read the case and submit your response. Your response may be selected for online publication. Submission deadline is April 30.
JAMA Patient Page
For your patients: Information about anal cancer.
(SEE ARTICLE) |
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Audio Summary, (Latest) |
| Description: This summary covers the issue of May 8, 2008. Featured are articles on hyperglycemia and adverse pregnancy outcomes, metformin plus insulin for the treatment of gestational diabetes, sudden cardiac arrest and early repolarization, left cardiac sympathetic denervation for catecholaminergic polymorphic ventricular tachycardia, an immunodeficiency disease with RAG mutations and granulomas, and targeting tumor angiogenesis; a review article on tumor angiogenesis; a case report of a man with anergia and anhedonia associated with cardiovascular surgery; and Perspective articles on long-term care and the 2008 election and on etiquette-based medicine. |
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Audio Summary, (May 1, 2008) |
| Description: This summary covers the issue of May 1, 2008. Featured are articles on hypertension in the very elderly, the shared genetic causes of childhood-onset cardiac hypertrophy, gene mutations and outcomes in cytogenetically normal AML, microRNA expression in cytogenetically normal AML, and a behavioral intervention to improve obstetrical care; a review article on the nonsurgical management of obesity in adults; a Clinical Problem-Solving article entitled “Back to Basics”; and Perspective articles on public opinion and health care and on the FDA, preemption, and the Supreme Court. |
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Audio Summary, (April 24, 2008) |
| Description: This summary covers the issue of April 24, 2008. Featured are articles on stents versus coronary-artery bypass grafting for left main coronary artery disease, home AEDs for sudden cardiac arrest, pyruvate kinase deficiency and malaria, mutations in the iodotyrosine deiodinase gene and hypothyroidism, ezetimibe use in the United States and Canada, and mast cells and pancreatic cancer; a review article on artesunate for severe falciparum malaria; a case report of a man with rheumatoid arthritis and lymphadenopathy; and Perspective articles on trying times at the FDA regarding the safety of imported pharmaceuticals, on playing “Kick the FDA”, and on eliminating blinding trachoma.
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Audio Summary, (April 17, 2008) |
| Description: This summary covers the issue of April 17, 2008. Featured are articles on weekly paclitaxel and breast cancer, intensive care for extremely premature newborns, YKL-40 levels and asthma, pharmaceutical promotion to physicians and first amendment rights, tectonic shifts in the health information economy, electronic health records and medical research, and grassroots activism and physician supply; review articles on the irritable bowel syndrome and on the management of very low birth weight; a case report of a newborn infant with apnea and seizures; and Perspective articles on personally controlled online health data, on avoiding the pitfalls of going electronic, and on the physician workforce crisis. |
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Listen to the Lancet, (Latest) |
| Description: Teenage smoking is a global public-health problem. In this week's podcast Professor Rhona Campbell outlines the results of the ASSIST (A Stop Smoking In Schools Trial) training programme. Smoking rates reduced by nearly a quarter in schools using peer-group leadership to encourage teenagers to quit compared with a conventional teacher-led educational approach.
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Listen to the Lancet, (May 3, 2008) |
| Description: Authors of a research Article discuss in this week's podcast how two genetic variants of key biological proteins increase both the risk of osteoporosis and osteoporotic bone fractures. As these variants are present in more than one in five people, the investigators conclude that there is a potential role for screening. An accompanying Comment describes the report as an important step towards understanding the genetic basis of osteoporosis. |
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Listen to the Lancet, (April 19, 2008) |
| Description: A randomised trial highlights how multislice computed tamography (MSCT) without ultrasonography of the leg is a reliable technique for detecting pulmonary embolism. Lead author Marc Righini (Geneva University Hospital, Switzerland) discusses the study in this week's podcast. |
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Listen to the Lancet, (Latest) |
| Description: The pieces are increasingly in place to achieve the Secretary General's vision for universal coverage and make rapid gains toward ending malaria deaths in Africa. With one child dying every 30 seconds from malaria in Africa, we have not a moment to lose'. In a joint podcast between The Lancet and The Lancet Infectious Diseases, Sally Hargreaves assesses renewed efforts to scale up prevention and treatment of malaria, coinciding with World Malaria Day on April 25. |
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Listen to the Lancet, (March 27, 2008) |
| Description: John McConnell and Richard Lane discuss highlights from the April issue, including the Leading Edge Editorial commenting on the US Food and Drug Administration proposal for superiority trials to be required before the licensing of anti-infective drugs. Also discussion of a review on syphilis, a sexually transmitted disease whose incidence is increasing after rapid decline in the 1980s and 1990s. |
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Listen to the Lancet, (February 25, 2008) |
| Description: Sally Hargreaves discusses highlights from the March issue: a review about the emergence of multidrug-resistant Enterobacteriaceae that produce extended-spectrum Beta-lactamases (ESBLs) within the community setting, an important cause of urinary-tract infections. Also discussed is a feature and the editorial about human papilloma (HPV) vaccination programmes, and the review about Whipple's disease, a condition which is both rare and poorly understood. |
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Listen to the Lancet, (Latest) |
| Description: Editor Helen Frankish discusses highlights from the May issue: results from the INTERACT trial showing how intensive blood pressure lowering could be beneficial for people who have had intra cranial haemorrhage; also discussion of a genetic study identifying a gene mutation involved in amyloid lateral sclerosis, and a review of stroke in children. |
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Listen to the Lancet, (March 19, 2008) |
| Description: Editor Helen Frankish discusses highlights from the April issue: including the EPITHET study of alteplase treatment 3-6 hours after a stroke, and donepezil treatment in patients with CADASIL, a genetic form of vascular dementia. |
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Listen to the Lancet, (February 25, 2008) |
| Description: Editor Helen Frankish discusses highlights from the March issue: including research Articles about a genetic clue to the cause of dystonia, a neurological disorder relating to Parkinson's disease; and a study identifying older age (68 years) as a risk factor for stroke among people given stenting rather than Endarterectomy to unblock the carotid artery. |
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Listen to the Lancet, (Latest) |
| Description: Editor David Collingridge discusses highlights from the May issue: the natural history of cervical intraepithelial neoplasia; the effect of screening on prostate-cancer mortality in the USA and UK; and the launch of a series of reviews about cancer in indigenous populations, starting this month with cancer among indigenous Polynesians.
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Listen to the Lancet, (April 1, 2008) |
| Description: Editor David Collingridge discusses highlights from the April issue including: encouraging results from the START trials suggest fewer fractions of radiotherapy could revolutionise treatment of early stage breast cancer; how a phase II study investigating yttrium-90 labelled ibritumomab could have an important future role in the treatment of follicular non-Hodgkin lymphoma, and finally the pressing need for increased recruitment of adolescents and young adults in to cancer trials. |
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Listen to the Lancet, (March 1, 2008) |
| Description: Dr David Collingridge, Editor of The Lancet Oncology, discusses highlights of the March issue in the first Lancet Oncology podcast. Two main topics are discussed: a research article highlighting how individuals in the United States who are under-insured or who have no medical insurance are at an increased risk of presenting with late-stage cancers; non-whites are at a similarly increased cancer risk. Also featured is a Dutch study showing the potential benefits of a shared-care programme between family doctors and oncology clinics for the long-term follow-up of individuals diagnosed with cancer in childhood. |
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May 6